Further ROC curves showed that EGFL7 (AUC 0.904, 95% CI (0.847–0.961)), ITGB3 (AUC 0.943, 95% CI (0.903–0.984)), and KLF2 (AUC 0.875, 95% CI (0.807–0.943)) could distinguish MM patients from health donors, and the sensitivity and specificity of EGFL7, ITGB3, and KLF2 were 0.750 and 0.933, 0.861 and 0.900, and 0.625 and 0.967, respectively, at the best cut-off points (Fig. 1B). Here, EGFL7 is linked to Miyoshi myopathy.