(2) EGFL7 could regulate extracellular signal-regulated kinase (ERK), signal transducer, and activator of transcription 3 (STAT3) and integrin signaling cascades to induce endothelial cell activities and form angiogenic regulation in the bone microenvironment, which further promoted MM progression, thereby related to worse prognostic risk stratification (ISS/R-ISS) and poor survival in MM patients [4]. The gene discussed is EGFL7; the disease is Miyoshi myopathy.