Genes regulated by this pathway include the type IIFN-encoding genes IFNA1 and IFNB. Inhibition of the pathway by knocking down IWS1,or by rescuing the IWS1 knockdown with the IWS1 mutant IWS1-S720A/T721A, resulted inlow expression of type I IFNs and in cellular sensitization to viral infection andreplication and virus-induced, caspase-mediated cell death. Here, SGCG is linked to viral infectious disease.