If the phosphorylation of IWS1 by AKT3 is required for theinduction of type I IFNs, as the data presented in this report indicate,inhibition of AKT prior to viral infection should block the induction of ISGs.To address this hypothesis, we treated NCI-H522 cells with 5 μM MK2206, or withthe vehicle (DMSO). The gene discussed is AKT1; the disease is viral infectious disease.