Importantly, these results were in agreement withRNA-Seq data derived from 516 lung adenocarcinoma patients in The Cancer GenomeAtlas (TCGA) LUAD database, which revealed negative correlations between theexpression of IWS1 and JUN, HSPB3 andIFNA1 (Supplementary Fig. 1b). The gene discussed is JUN; the disease is lung adenocarcinoma.