APP and Cognitive impairment: Similarly, in APP-KI mice subcutaneous or intravenous injection of human antibody #129 (Supplementary Fig. 11f) recovered MARCKS phosphorylation at Ser46 (Supplementary Fig. 11g), decrease of dendritic spines (Supplementary Fig. 11h), cognitive impairment (Supplementary Fig. 11i), and extracellular Aβ aggregates (Supplementary Fig. 11j).