However, genomic analysis of ESCC, adjacent low-grade intraepithelial neoplasia (LGIN), and high-grade intraepithelial neoplasia (HGIN) revealed that the genomic variant profiles of LGIN and HGIN are similar to that of ESCC26, including the profile for TP53 variants. The gene discussed is TP53; the disease is intraepithelial neoplasia.