In conclusion, obesity-associated immunometabolic factors including LDL-cholesterol, FABP4, and leptin were associated with a higher iNKT cell IFN-γ response across all disease groups, while HDL-cholesterol and insulin sensitivity (QUICKI) were associated with a higher IL-4 response. The gene discussed is IFNG; the disease is obesity due to melanocortin 4 receptor deficiency.