ROC curves analysis demonstrated high accuracy for both cNfL and pNfL in the discrimination of PD from MSA (CSF: AUC 0.991, 95.7% sensitivity, 100% specificity, cut-off 1196 pg/mL; plasma: AUC 0.972, 90.3 sensitivity, 96.4% specificity, cut-off 17.2 pg/mL) and PSP/CBS (CSF: AUC 0.940, 97.4% sensitivity, 80.8% specificity, cut-off 1057 pg/mL; plasma: AUC 0.936, 88.7% sensitivity, 87.8% specificity, cut-off 16.6 pg/mL) (Fig. 1d–f, Table 3). This evidence concerns the gene CBS and Parkinson disease.