EGFR and non-small cell lung carcinoma: Notably, while nebivolol significantly inhibited cell proliferation in PC-9 cells bearing wild-type Ras, it exhibited little effects in A549 cells that possess K-RasG12S (Supplementary Fig. 8h), indicating that EGFR signaling is mainly responsible for the inhibitory effects of nebivolol on cell proliferation of NSCLC.