As shown in Fig. 3o−q, the Ade-Cre-induced expression of EGFRL858R/T790M effectively drove lung tumor formation, which was significantly inhibited by lentiviral expression of HA-FBXL2, as evidenced by micro-CT scanning, measurement of lung tumor numbers, and H&E staining of tumor sections. This evidence concerns the gene FBXL2 and neoplasm.