While several studies show that FBXL2 can promote the degradation of free p85β or IP3R3 to inhibit autophagy and apoptosis27,28, FBXL2 can also target several oncoproteins, including cyclin D2, cyclin D3, or Aurora B for proteasomal degradation, and consequently inhibit cell proliferation and tumor growth24,25,43. Here, ITPR3 is linked to neoplasm.