To further substantiate the inhibitory role of FBXL2 on the growth of EGFRL858R/T790M-driven NSCLC in vivo, we generated a Cre-inducible Rosa26-LSL-EGFRL858R/T790M lung tumor mouse model (Supplementary Fig. 4e). This evidence concerns the gene FBXL2 and non-small cell lung carcinoma.