Through clinical tissue samples of gastric cancer, MYH9 was positively correlated with the depth of invasion and lymph node metastasis of gastric cancer, and MYH9 promoted the progression of esophageal cancer, which was closely related to lymph node metastasis and pathological grade of patients with esophageal cancer. This evidence concerns the gene MYH9 and metastatic malignant neoplasm in the lymph nodes.