Furthermore, tumor formation tests in vivo showed that the xenografts formed by LCCs knocked down by MYH9 grew slowly, tumor size was smaller, and tumor weight was lighter, and the expression trend of metastasis molecule N-cadherin, malignant proliferation marker Ki67 and stem cell markers CD44 and CD133 in xenografts was the same as that of MYH9. This evidence concerns the gene PROM1 and neoplasm.