The results revealed that [1]: apatinib can inhibit the malignant growth of gliomas; [2] apatinib downregulated THBS1 gene expression, and THBS1 gene downregulation inhibited malignant glioma growth; and [3] THBS1-OE can counteract the inhibitory effect of apatinib. Here, THBS1 is linked to malignant glioma.