The results revealed that [1]: apatinib can inhibit the malignant growth of gliomas; [2] apatinib downregulated THBS1 gene expression, and THBS1 gene downregulation inhibited malignant glioma growth; and [3] THBS1-OE can counteract the inhibitory effect of apatinib. This evidence concerns the gene THBS1 and central nervous system cancer.