The proportion of coronary events due to non-obstructive coronary atherosclerosis in epidemiological studies is, however, low and a large proportion of these have been shown to be caused by atherosclerosis.1 Moreover, high concentrations of IL6 have been seen in women with Takotsubo.27 In addition, since we excluded participants with prevalent CVD, the analysed group of women had lower prevalence of risk factors possibly leading to a lower incidence rate of CVE, thus resulting in reduced power to detect an association. This evidence concerns the gene IL6 and atherosclerosis.