Finally, we found eight DM-CpGs that were consistently associated with corresponding gene expression, important genetic variation (rs7498665, SH2B1), and systemic inflammation (MIP1B): these were cg12040201 in CSMD3, cg04088932 in SH3BP4, cg24328539 in GATM, cg05401945 in CCDC66, cg07880109 in KIAA0748, cg10760299 in GATM, cg10825530 in SOX6, and cg13534536 in AFAP1. CSMD3 is considered a driver gene in liver cancer [60]. This evidence concerns the gene CCDC66 and liver cancer.