This review on the effect of drugs on SCD cognition and healthy individuals included the main pharmacological cognitive enhancement (CED or smart drugs, acetylcholinesterase inhibitors, Memantine, antidepressant) and herbal extracts (Panax ginseng, Gingko biloba, and Bacopa monnieri). Based on this review, there is no conclusive argument to recommend pharmacological cognitive enhancement or herbal extracts on SCD or worried-well individuals. This evidence concerns the gene ACHE and Schnyder corneal dystrophy.