For instance, lncRNA PVT1 triggers cytoprotective autophagy and promotes PC progression by binding to miR-20a-5p [25], while the lncRNA LINC00261 inhibits c-Myc-mediated aerobic glycolysis in PC by sponging miR-222-3p and sequestering IGF2BP1 [26]. Here, PVT1 is linked to pachyonychia congenita.