SOD1 and amyotrophic lateral sclerosis: Motor neuron degeneration is evident pre-symptomatically between 60 and 90 days of age in the gold standard mutant superoxide dismutase 1 G93A (mSOD1G93A) mouse model of ALS (B6.Cg-Tg(SOD1*G93A)1Gur/J #004435; Jackson Laboratory) [8].