In conclusion, miR-30a-5p was upregulated in inflammatory tissue of periodontitis rat model and MC3T3-E1 cell line, miR-30a-5p inhibitorS would promote osteogenesis and relieve inflammation by targeting Runx2 in MC3T3-E1 cell line under LPS-induing, which were summarized in Fig. 6. The gene discussed is RUNX2; the disease is periodontitis.