In their study, patients treated for cerebral infarction with intravenous tPA within 4.5 h after symptom onset were older than those beyond 4.5 h (< 4.5 h: 72.2 ± 10.4 years old; > 4.5 h: 69.02 ± 13.2 years old). The gene discussed is PLAT; the disease is cerebral infarction.