Moreover, the down-regulation of miR-107 may cause cell cycle and proliferation due to the up-regulation of CDK6 (also targeted by miR-103) and CDK8 and metastasis and tumor growth because of the up-regulation of BDNF as well as indirect regulating of the P13K/AKT signaling pathway [40, 41]. Here, AKT1 is linked to neoplasm.