Not only EGFR facilitates proliferative signaling through downstream signaling pathways, i.e. PI3K/AKT/mTOR and RAS/ERK, EGFR signaling pathway is one of the activated pathways in lung cancer and employs downstream RAS or ERK pathways to direct proliferative signaling for lung cancer cells [40]. Here, AKT1 is linked to lung carcinoma.