E2F3 and neoplasm: Furthermore, in [48], L. Chen et al. defined E2F3 as a transcriptional activator that is a target gene of miR-17 capable of increasing the cellular proliferation via boosting the G1/S transition; besides, the down-regulation of E2F3 might be due to the molecular mechanism employed by up-regulation of miR-17 as a tumor suppressor.