After pathway enrichment, we analyzed three pathways, including non-small cell lung cancer, cell cycle, and p53 signaling pathways as the remarkable enriched pathways based on average ES and their common involved miRNAs, including has-miR-15b, hsa-miR-106a, has-miR-17, has-miR-103 and has-miR-107. The gene discussed is TP53; the disease is non-small cell lung carcinoma.