The PRF model for LCOS includes BCr (OR 1.85; 95% CI 0.95–3.59), creatinine clearance rate (CCr) (OR 0.46; 95% CI 0.32–0.67), hemoglobin (Hb) (OR 0.73; 95% CI 0.58–0.91), PAH (OR 1.34; 95% CI 0.96–1.86), and hypertension (OR 1.70; 95% CI 0.94–3.05) (Table 2). The gene discussed is GSTM1; the disease is pulmonary arterial hypertension.