The anti-inflammatory mechanisms of ALD-R491 could also create multiple actions that are novel and different from existing agents and highly sought after for their specific potential against the hyperinflammation of COVID-19—a direct Treg activation, as shown in this study, and a potential inhibition of NLRP3 inflammasome activation, as a previous study suggested (22). The gene discussed is NLRP3; the disease is COVID-19.