IL6 and cancer: Furthermore, higher DNA methylation in the IL-6 promoter was found in a minor allele (C) at rs1800796; in contrast, the derived C allele at rs1800795 was associated with lower DNA methylation in colorectal cancer tissues (Fig. 1g) and another cancer type (see Fig. S1 in the supplemental material) in a publicity available data set, Pancan-meQTL (25).