IL6 and COVID-19: The net effect of this high-producing Caucasian IL-6 genotype on COVID-19 outcome might be neutral, as higher basal levels of IL-6 are beneficial for the activation of immune response and viral clearance, but continual synthesis of IL-6 exerts a pathological effect (37), which may explain the lack of IL-6 polymorphisms association with COVID-19 in European populations.