However, high level expression of FOXC2 and PABPC1 in gastric cancer (45,46) as well as in the activation of epithelial mesenchymal transition (EMT) and metastasis by overexpression of FOXC2 in cancer cells (47) are potentially consistent with their role in suppressing the p16INK4a-dependent senescence. This evidence concerns the gene FOXC2 and gastric cancer.