Furthermore, TAOK3 protein levels were increased in the livers of mice with HCC induced by the administration of diethylnitrosamine (DEN) combined with a high-fat diet or treatment with carbon tetrachloride (CCl4) combined with a choline-deficient l-amino-acid-defined (CDAA) diet, when compared with those observed in the samples collected from healthy chow-fed control mice (Supplementary Figure S4). This evidence concerns the gene TAOK3 and hepatocellular carcinoma.