As HFOs are synchronous with GABAergic potentials before seizure onset, in multiple models of epilepsy (Köhling et al., 2001; Trevelyan et al., 2006; Gnatkovsky et al., 2008; Jefferys et al., 2012), as well as being elevated during the bursts in our model, future studies may look at how the prolongation of the bursts could initiate seizures in Wwox S-KO mice. Here, WWOX is linked to epilepsy.