WWOX and epilepsy: Cortical hypomyelination is present in a rat model with impaired WWOX function (Tochigi et al., 2019), and in mouse Wwox knockout models (Cheng et al., 2020; Repudi et al., 2021); however, hypomyelination alone does not necessarily cause epilepsy (Graciarena et al., 2019; Maas et al., 2020).