Loss of function of WW domain-containing oxidoreductase (WWOX) is associated with early infantile epileptic encephalopathy (WOREE/EIEE28), a neurological disorder characterized by severe and uncontrollable epileptic seizures; however, it is currently unknown how a mutation in Wwox results in this epileptic disorder (Abu-Remaileh et al., 2015; Mignot et al., 2015; Valduga et al., 2015; Helbig and Abou Tayoun, 2016; McTague et al., 2016; Tanna and Aqeilan, 2018; Piard et al., 2019). This evidence concerns the gene WWOX and genetic developmental and epileptic encephalopathy.