MYH14 and cardiomyopathy: The myosin shares many of the critical structural elements common to myosins including loops involved in nucleotide binding (e.g., P-loop, switch-1, and switch-2), actin binding (e.g., the cardiomyopathy loop, loop 2, loop 4, and the helix-loop-helix domain), and mechanical elements (e.g., relay helix, SH1 and SH2 helices, and converter domain) (Fig. 1B).