It should be noted that if the DDI potential of an inhibitory drug is being investigated, as is in the case of amiodarone acting as a P‐gp inhibitor, it may be prudent to further evaluate multiple (vs single) dose administrations of amiodarone to investigate the impact of a worst‐case scenario of steady‐state amiodarone concentrations on OM PK and confirm the results observed in the current clinical study. This evidence concerns the gene PGP and ocular melanoma.