In these genes, ANPEP, CD69, ITGAL, PECAM1, PTPRC, CD34, ITGA1, CCL2, SOX2, and EGFR were identified as key DEGs in the treatment of resveratrol in NSCLC, then expression analysis and survival analysis of these ten genes demonstrated that ANPEP, CD69, ITGAL, and PTPRC were the potential candidate genes significantly correlated with resveratrol treatment in NSCLC. The gene discussed is CD69; the disease is non-small cell lung carcinoma.