Mutations affecting TERT promoter and other classical driver genes, such as TP53 (cell cycle), CTNNB1, AXIN1 (Wnt signaling), ARID1A, ARID2 (chromatin remodeling), RPS6KA3, NFE2L2, KRAS, PIK3CA, CDKN2A, CCND1/FGF19, and VEGFA are found only in HCC and not in dysplastic nodules [65, 66]. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.