In our results, some of the differentially methylated genes in EHMT2 + MCL cases have also been reported with recurrent genetic alterations in lymphoma, such as ALK, DUSP22, NCOR2, RORA, DLC1, JAG1/2, JAK1, NOTCH4, and CD1938–45. The gene discussed is NOTCH4; the disease is mantle cell lymphoma.