The ratio of individuals with TP53 pathogenic variant among patients with adrenocortical cancer is 50–100% for those aged < 18 years (median of 75%) and 4–33% for those aged ≥ 18 years (median of 13%) [21, 25, 26, 35–41]; thus, in adrenocortical cancer, LFS is suspected, regardless of the patient’s age. The gene discussed is TP53; the disease is adrenal cortex carcinoma.