TP53 and osteosarcoma: When osteosarcomas are comprehensively analyzed, compared to general population, the OR was 1.69 (95% CI: 1.01–2.80) [65], while the HR was 15.7 (P < 0.0001) within the family [66]; thus, the penetrance of osteosarcoma is significantly higher for individuals with TP53 pathogenic variant.