RUNX1 and acute myeloid leukemia: Introduction: Familial platelet disorder with associated myeloid malignancies (RUNX1-FPD, FPDMM, FPD/AML, MIM 601399) is typically characterized by thrombocytopenia, functional platelet defects, and a ~40% risk to develop hematological malignancies, mainly MDS and/or AML.