On the other hand, a recent study showed that increased STAU1-mediated degradation of zinc-finger protein 331 (ZNF331) (a transcription suppressor which plays tumor suppressor function in different cancers including gastric and colorectal cancers) mRNAs is associated with the growth of glioma cells (U87 and U251) and directly correlates with tumor grades (stages III and IV). Here, ZNF331 is linked to central nervous system cancer.