The chromosomal 1q21-24 is identified as the susceptible region of T2DM, and the retinoid X receptor-γ (RXR-γ) rs10918169, apolipoprotein A2 (APOA2) rs6413453, calsequestrin 1 (CASQ1) rs617698 and dual specificity phosphatase 12 (DUSP12) rs1503814 are screened as the susceptible genes and loci of T2DM belonging to this region [23]. This evidence concerns the gene APOA2 and type 2 diabetes mellitus.