RXRA and obesity due to melanocortin 4 receptor deficiency: It is likely to bring adverse consequences for both mothers and their offspring, for instance, pregnant women with GDM are often at a relatively higher risk of T2DM, obesity, dyslipidemia, preterm birth, spontaneous abortion, respiratory distress syndrome of newborn etc. Studies showed that the RXR-α/γ proteins perform the function of transcription factors by binding as heterodimers to the specific sequences in the promoter of target genes of VD and retinoid pathways, which are closely related to diabetes, islet function, and glucose and lipid metabolism.