INS and type 2 diabetes mellitus: In addition, studies have shown that the genetic variation rs10830963 of MTNR1B gene is associated with the pathogenesis of T2DM by affecting the expression of MTNR1B [21], and carrying the MTNR1B rs10830963G allele significantly increased the odds of antenatal insulin therapy (AIT) in pregnant women of GDM with pre-pregnancy BMI > 29 kg/m2 [22].