We observed a rapid loss of ribosomal S6 protein phosphorylation in Paneth cells as early as day 3 post infection (Figure 3A), and this loss preceded the loss of Paneth cells detected by immunofluorescence staining (Figure 3A) or quantitative analysis of Paneth cell-specific transcripts (Figure 3B, Figure 3—source data 1 and data not shown). Here, RPS6 is linked to infection.