SPINK7 and esophageal squamous cell carcinoma: Previous research has shown that miR-1322 can regulate ECRG2 and is a potential diagnostic biomarker for esophageal squamous cell carcinoma.40 In addition, Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma.41 We used a public prediction database to confirm that miR-1322 directly regulated CCL20 expression.