TSLP and colorectal carcinoma: 38 Han et al. also found that E. coli (strain DH5α) increases TSLP (thymic stromal lymphopoietin) expression in THP-1 and HL-60-derived macrophage, leading to systemic inflammatory reaction and organ dysfunction.39 Despite having good immunogenicity, E. coli failed to promote CRC tumorigenesis in our AOMD/DSS model, and the results were not statistically significant.