Upregulation of chemokine expression plays a vital role in the progression of cancer.11 To investigate whether chemokines were involved in F. nucleatum-induced CRC metastasis, we used an RNA-seq profiles previously developed by our team.15 Heatmap and volcano map showed that CCL20 was one of the most differentially upregulated chemokines in F. nucleatum-infected LoVo cells compare with PBS treatment (Figure 2(a-c)). Here, CCL20 is linked to cancer.