Additionally, a recent study has shown that microbiota transplanted from Ace2 knockout mice to germ-free animals resulted in severe colitis after dextran sulfate sodium challenge indicating an important relationship between the microbiome, Ace2, and intestinal homeostasis.6 The reduced levels of Ace2 as a consequence of the intestinal microbiome therefore may have a protective role against SARS-CoV-2 infection by limiting potential receptors for viral entry via the colon. This evidence concerns the gene ACE2 and colitis.