Obesity alters the expression of cell adhesion molecules VCAM‐1, ICAM‐1, and E‐selectin, modifying the expression of structural proteins such as pulmonary endothelial junctional adherens proteins (VE‐cadherin and β‐cathenin) by augmenting inflammation and disrupting the functions of the endothelial barrier.36 The gene discussed is SELE; the disease is obesity due to melanocortin 4 receptor deficiency.