TP53 and neoplasm: Meanwhile, several characteristic genetic mutations in tumor cells such as RAS, PI3K, and P53 could substantially boost the energy metabolism in tumor cells and affect the initiation and progression of ferroptosis therein.[120, 121, 122] It could be thus concluded that disrupting the tumor energy metabolic pathways would not only alter the ferroptosis sensitivity of mutated tumor cells but also breading down their antioxidative defense to promote ferroptosis.