CD274 and neoplasm: Typically, it was demonstrated that CD8+ T cells activated by immunotherapy could release IFNγ to inhibit the expression of SLC7A11 in tumor cells and impair the cystine uptake, thus inducing tumor cell ferroptosis.[128] Extending from the interaction between ferroptosis and immunotherapy, the authors designed an engineered cystine‐degrading enzyme called cyst(e)inase, which could synergize with PD‐L1 immunotherapy for enhanced tumor inhibition efficacy.