Extending from the role of AMPK in ferroptosis regulation, it has been reported that liver kinase B1 (LKB1), an upstream of AMPK, could also affect ferroptosis in the cellular environment.[98] Typically, LKB1 is a master serine/threonine kinase and involved in numerous cellular events, especially for the metabolic response to tumor cells under energy stress.[99] Gao et al. This evidence concerns the gene STK11 and neoplasm.