IL1B and infection: Our current study confirmed this finding, as there was increased expression of IL‐1β and cleaved Caspase‐1 in all M.tb strain infections, and most notably, we discovered that H37Rv infection in macrophages induced the expression of much higher levels of IL‐1β and cleaved Caspase‐1, implying that Mtb‐induced pyroptosis is associated with the virulent nature of M.tb strain, which partly explains the pathogenesis of virulent stains of Mtb infection.