Thus, CuET administered alone promotes accumulation of NPL4 within the nondissolvable cellular fraction, an effect that was reduced in two cell lines, U‐2‐OS osteosarcoma and breast cancer‐derived MDA‐MB‐231 when exposed to a combined CBD + CuET treatment (Fig. 1D, Fig. S1A). Here, NPLOC4 is linked to breast carcinoma.