An observational study with pooled participants from the Three-City study and 4 US cohorts (Nurses’ Health study, Women’s health study, Chicago Health and Aging project and Rush Memory and Aging projects) found no interactions between fish consumption and APOE ε4 and 11 other AD-related genes in relation to cognitive decline among older adults (age > 65 years) [31]. The gene discussed is APOE; the disease is Mental deterioration.