Finally, NINJA mice have the potential to be used in all GEMM models with (1) Cre-inducible promoters in different organs (i.e., KP × PDX1-CreER for pancreas), and (2) lox-stop-lox “floxed” mutations (i.e., Braf CA-V600E Ptenflox/flox for melanoma). Here, PDX1 is linked to melanoma.