‘Brain only’ mTORopathiesGATOR1-related focal epilepsies (germline DEPDC5, NPLR2 and NPRL3)Focal cortical dysplasia type II (somatic MTOR, AKT3, PIK3CA and RHEB)Hemimegalencephaly (somatic MTOR, AKT3, PIK3CA, RHEB and PTEN)Infantile-onset developmental and epileptic encephalopathies (germline SZT2 and KPTN)a. The gene discussed is PIK3CA; the disease is focal epilepsy.