The more recent discovery of epilepsy-causative NPRL2 and NPRL3 variants and the greater length of the DEPDC5 transcript (5551 bp) compared with NPRL2 (1700 bp) and NPRL3 (2881 bp) have been offered as explanations for the increased frequency of DEPDC5-associated epilepsies.11 This evidence concerns the gene DEPDC5 and epilepsy.