In a mouse model of DEPDC5-related FCD developed using in utero electroporation and CRISPR/Cas9 technology to recapitulate a second-hit somatic mutation in cortical pyramidal cells, Depdc5 inactivation led to abnormal dendritic and spine shaping, increased excitatory transmission and epileptogenesis.34 Here, DEPDC5 is linked to fleck corneal dystrophy.