SERPINE1 and endothelial dysfunction: Third, we showed acute MIS-C patients had high levels of plasminogen activator inhibitor-1 (PAI-1), a marker of endothelial dysfunction that amplifies neutrophil-mediated inflammation via multiple mechanisms (Zmijewski et al., 2011; Ren et al., 2015) and that is raised in multiple inflammatory conditions including trauma, sepsis and in adult COVID-19 patients (Zuo et al., 2021).