Although it has been reported that the expression of CRABP2 is lower in ESCC, the prognostic value of CRABP2 and its relationship with the expression of competitive protein FABP5 is uncertain, as well as the relationship with the ratio of CRABP2 and FABP5 and prognosis. This evidence concerns the gene CRABP2 and esophageal squamous cell carcinoma.