CRABP2 regulates the HIPPO signaling pathway, large tumor suppressor (Lats1) stability promotes the invasion and metastasis of ER-breast cancer; in highly metastatic lung cancer cell lines, overexpression of CRABP2 can increase the level of RNA binding protein (HUR) and promote lung cancer cell invasion, migration, and anti-apoptosis through the transduction of integrin β1/FAK/ERK signaling pathway and the high expression of CRABP2 is associated with lymph node metastasis, poor overall survival, and increased recurrence. The gene discussed is LATS1; the disease is breast carcinoma.