CRABP2 regulates the HIPPO signaling pathway, large tumor suppressor (Lats1) stability promotes the invasion and metastasis of ER-breast cancer; in highly metastatic lung cancer cell lines, overexpression of CRABP2 can increase the level of RNA binding protein (HUR) and promote lung cancer cell invasion, migration, and anti-apoptosis through the transduction of integrin β1/FAK/ERK signaling pathway and the high expression of CRABP2 is associated with lymph node metastasis, poor overall survival, and increased recurrence. Here, PTK2 is linked to metastatic malignant neoplasm in the lymph nodes.