Considering the fact that there is a cross-talk between signaling pathways (PI3K/AKT/mTOR and Wnt/β-catenin/TGF-β) and the influence of ABC transporter proteins in chemoresistance, further detailed studies are required to target multiple pathways simultaneously to disseminate the underlying molecular mechanism of PI3K/AKT signaling-mediated tumor invasion and metastasis. The gene discussed is AKT1; the disease is neoplasm.