KCND3 and myocardial infarction: In rat models of myocardial infarction, the calcineurin inhibitor cyclosporin A can significantly inhibit ventricular remodeling and hypertrophy, improve diastolic function, inhibit a decrease in Ito current density in ventricular myocytes, and downregulate Kv4.2 and Kv4.3 mRNA and protein expression [14].