Thus, the role of CREB3L1 activation in tumor progression should be analyzed in a broader context of changes in cancer cells related to the expression of a mesenchymal phenotype of the tumor as well as signaling pathways including CREB3L1 DNA methylation,16 alterations in histone modifications, regulation of RNA processing,45 and translational deregulation.46 The gene discussed is CREB3L1; the disease is neoplasm.