Consistent with this possibility are recent studies showing that the CREB3L1 involvement in tumor progression ranges from suppression16,43 to promotion of metastatic dissemination in tumors that have activated both protein kinase-like ER kinase (PERK) and have undergone an epithelial-to-mesenchymal transition (EMT) program.44 This evidence concerns the gene EIF2AK3 and neoplasm.