Thus, the role of CREB3L1 activation in tumor progression should be analyzed in a broader context of changes in cancer cells related to the expression of a mesenchymal phenotype of the tumor as well as signaling pathways including CREB3L1 DNA methylation,16 alterations in histone modifications, regulation of RNA processing,45 and translational deregulation.46 This evidence concerns the gene CREB3L1 and cancer.