CREB3L1 and cancer: The most prominent nuclear translocation of CREB3L1 was demonstrated in cancer cells derived from patient #3665 (stage IIIC high-grade serous carcinoma), after treatment with DOX and the combination of OVV/DOX (Rd = 0.59 and 0.97, respectively), despite the lowest level of CREB3L1 expression among the analyzed specimens (Figure 6A).