MAPT and supranuclear palsy, progressive, 1: The neurobiological definition of PSP has emerged to focus a unique neuropathological pattern characterized by formation of insoluble aggregates composed mainly of 4‐repeat isoforms of the microtubule‐associated protein tau in the shape of globose neurofibrillary tangles, neuropil threads, oligodendroglial coiled bodies, and specifically tufted astrocytes.4, 5