CD4 and AIDS: Similarly, a randomized clinical trial of prednisolone (5 mg/day, two years) applied in ART naïve patients showed a significant decrease in immune activation (sCD14, suPAR, and CD38/HLA-DR/CD8+) and an increase in CD4+ T counts, while no significant effect on the primary endpoint of HIV disease progression to AIDS although viral load increased quickly than placebo [78].