A recent study identified OPG as an important regulatory molecule in vascular diseases, including cerebral atherosclerosis, and showed its contribution to vessel calcifications in patients with T2DM, suggesting its possible role in the progression of vessel calcification lesions of other vascular beds, such as lower extremity PAD, in patients with diabetes [107]. The gene discussed is TNFRSF11B; the disease is type 2 diabetes mellitus.